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</div> <div id="vzhd3htz5lj" class="detail-content wbwr f32 lh52 pt20 taj"><p>高尿酸血癥可能由遺傳因素、高嘌呤飲食、代謝異常、腎臟排泄障礙、藥物影響等原因引起。高尿酸血癥可通過調(diào)整飲食、增加飲水、藥物治療等方式干預(yù)。</p><p><img class="up_image_20111121" src="https://file.bohe.cn/fhfile1/M00/88/F2/ooYBAGjJCjiATkmIAAXf7CBtE7g732.jpg"></p><p>1、遺傳因素</p><p>部分高尿酸血癥患者存在遺傳性嘌呤代謝酶缺陷，如次黃嘌呤-鳥嘌呤磷酸核糖轉(zhuǎn)移酶缺乏癥。這類患者體內(nèi)尿酸生成過多，可能伴隨痛風(fēng)性關(guān)節(jié)炎或尿酸性腎結(jié)石。建議此類人群定期監(jiān)測血尿酸水平，避免高嘌呤食物攝入。</p><p>2、高嘌呤飲食</p><p>長期大量攝入動物內(nèi)臟、海鮮、濃肉湯等高嘌呤食物會導(dǎo)致外源性尿酸增加。啤酒中的鳥苷酸也會促進(jìn)尿酸合成。這類因素引起的高尿酸血癥通?？赏ㄟ^低嘌呤飲食改善，如選擇牛奶、雞蛋、新鮮蔬菜等低嘌呤食物。</p><p>3、代謝異常</p><p><img class="up_image_20111121" src="https://file.bohe.cn/fhfile1/M00/88/F2/ooYBAGjJCjiAa76LAAiCmXjR8wE505.jpg"></p><p>肥胖、胰島素抵抗等代謝綜合征患者常合并尿酸排泄減少。脂肪組織分解產(chǎn)生的酮體會競爭性抑制腎臟尿酸排泄。這類患者需要控制體重，可遵醫(yī)囑使用非布司他片、苯溴馬隆片等藥物調(diào)節(jié)尿酸代謝。</p><p>4、腎臟排泄障礙</p><p>慢性腎病、鉛中毒腎病等疾病會導(dǎo)致腎小管尿酸分泌功能受損。這類患者可能出現(xiàn)血肌酐升高伴尿酸排泄分?jǐn)?shù)降低。需治療原發(fā)病，必要時使用碳酸氫鈉片堿化尿液促進(jìn)尿酸溶解。</p><p>5、藥物影響</p><p>利尿劑如氫氯噻嗪片、免疫抑制劑如環(huán)孢素軟膠囊等藥物可能干擾腎小管尿酸轉(zhuǎn)運。使用這些藥物期間應(yīng)定期復(fù)查尿酸，必要時聯(lián)用別嘌醇片等降尿酸藥物。</p><p>高尿酸血癥患者每日飲水量建議達(dá)到2000毫升以上，可飲用蘇打水幫助堿化尿液。避免劇烈運動誘發(fā)痛風(fēng)發(fā)作，選擇游泳、騎自行車等低沖擊運動。若出現(xiàn)關(guān)節(jié)紅腫熱痛等痛風(fēng)癥狀，應(yīng)及時就醫(yī)完善尿酸測定和關(guān)節(jié)超聲檢查。</p></div> <div id="vzhd3htz5lj" class="f24 fc9 lh40 ta-j">免責(zé)聲明：本頁面信息為第三方發(fā)布或內(nèi)容轉(zhuǎn)載，僅出于信息傳遞目的，其作者觀點、內(nèi)容描述及原創(chuàng)度、真實性、完整性、時效性本平臺不作任何保證或承諾，涉及用藥、治療等問題需謹(jǐn)遵醫(yī)囑！請讀者僅作參考，并自行核實相關(guān)內(nèi)容。如有作品內(nèi)容、知識產(chǎn)權(quán)或其它問題，請發(fā)郵件至suggest@fh21.com及時聯(lián)系我們處理！</div> <div id="vzhd3htz5lj" class="pt40"> <a 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